Julian Pacheco

OHSU Vaccine & Gene Therapy Institute
M.S. Data Science, Willamette University
B.S. Biology, Portland State University
SCROLL
01

Story

I'm a biomedical researcher with more than four years in HIV immunology and nonhuman primate models at OHSU's Vaccine and Gene Therapy Institute. Over that time I came to believe that ingenuity wasn't what slowed discovery down. The data was.

Every new technique we introduced generated more data, faster and at greater complexity, yet I kept watching promising questions stall because no one had the time or tools to explore what we'd already collected. The researchers I learned from saw the same problem from different angles. Dr. Lydie Trautmann first brought me into the field, Dr. Hiroshi Takata mentored me across two labs, and Dr. Afam Okoye leads the group I work with now. Even on strong teams the constraint held. Our ability to measure biology had outpaced our ability to analyze it.

So I went after the other half of the toolkit, a master's in data science from Willamette University. There I built public health dashboards, data pipelines, and statistical and machine learning models of regional affordability. That work taught me to turn large, fragmented datasets into systems that support clearer questions, reproducible analysis, and better decisions. Now I apply those methods to immunology datasets that conventional approaches struggle to capture in full. This is work at the intersection of biology, data science, and machine learning.

My long term goal is translational. I want to move discoveries from biological measurement to therapeutic development and, eventually, to patients. Immunology is where this started, but my interests run wider, to new data types, new domains, and complex problems where better analysis can surface what would otherwise stay hidden. I'm open to wherever the next hard question lives, as long as it keeps challenging me and the work is worth doing.

Immunology
Data Science
Engineering
Public Health
Impact
02

Experience

2021 — Present
Research Assistant
Vaccine and Gene Therapy Institute · OHSU · Beaverton, OR
  • Contributed immune response analysis to a Phase 1b trial of lenacapavir, an FDA Breakthrough Therapy designated regimen now in Phase 2, joining a collaborative effort to bring this lifesaving treatment closer to market.
  • Built and ran multiparameter flow cytometry pipelines across human and NHP models, transforming high dimensional data into quantified results that anchored publications, presentations, and grant reporting.
  • Contributed to a multidisciplinary team designing longitudinal NHP and human studies, building time series data structures (viral load, cytokine, cell associated RNA/DNA) from in vivo and in vitro samples to study how SIV and HIV persist during treatment.
2020
Biological Field Technician
Bureau of Land Management ·(Contract)· Lakeview, OR
  • Built rigorous data collection and integrity practices in the field on a Greater Sage Grouse and juniper removal study, the same foundation of clean, reliable data that drives my work from raw inputs to analysis today.
  • Collected precise field data across a diverse range of instruments and methods, from vegetation and soil sampling to radio telemetry, nest assessments, and brood counts, building the technical versatility I carry across tools and platforms today.
03

Education

2026
M.S., Data Science
Willamette University · Salem, OR
2017
B.S., Biology
Portland State University · Portland, OR
04

Research & Contributions

Click a badge (Poster, Powerpoint, Paper) to view the source.

2026
Takata H, Pacheco J, et al. “RV550: IL-15 Superagonist N-803 at ART Interruption Enhances NK and T Cell Proliferation and Activation Prior to Viral Rebound.” Contributions featured.
Keystone Symposia — HIV Persistence, Remission, and Cure · Breckenridge, CO
Poster
2025
Cai Y, Takata H, Ferreira AM, Pacheco Mendez J, et al. “HIV-Specific T Cell Responses in Suppressed People with HIV-1 Receiving Lenacapavir, Teropavimab, and Zinlirvimab.” Contributions featured.
IAS 2025, Kigali, Rwanda · #OAA0205
Powerpoint
2025
Takata H, Pacheco J, et al. “RV550: IL-15 Superagonist N-803 With ART in Acute HIV Infection Enhances T and NK Cell Proliferation.” Contributions featured.
CROI 2025, San Francisco, CA · #0444
Poster
2025
Varco-Merth B, Marino A, Takata H, Pacheco J, et al. “IL-15 Superagonist at ART Initiation Expands SIV-Specific CD8+ T Cells in Blood and Lymphoid Tissues.” Contributions featured.
CROI 2025, San Francisco, CA · #309
Poster
2023
Takata H, Mitchell JL, Pacheco J, et al. “An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status.”
Cell Host & Microbe, 31(9):1494–1506.e4
Paper
2023
Mitchell J, Subra C, Julian Pacheco, et al. “Compartmentalized Clonal Expansions of CD8+ T Cells in CSF During Acute HIV Infection.” Contributions featured.
CROI 2023 (Virtual)
Poster
05

Toolkit

Data Analytics

  • Longitudinal Regression Analysis
  • Unsupervised Clustering
  • Time Series Analysis
  • Automation Exposure Analysis
  • pandas

Machine Learning

  • Supervised Classification & Regression
  • Feature Extraction & Classification
  • Dimensionality Reduction (PCA, TruncatedSVD)
  • Ensemble Model Optimization
  • Neural N0etwork Architecture
  • scikit-learn
  • TensorFlow

Data Engineering

  • ETL pipeline design (SQLAlchemy, Python)
  • Data modeling for Analytics
  • Pipeline Orchestration & Automation
  • Database Architecture & OptimizationB
  • Apache Airflow
  • dbt
  • DuckDB
  • Databricks

Languages

  • Python
  • R
  • SQL
  • Bash
  • C#
Open to opportunities

Let's build
something.

apacheco26@outlook.com